Abstract: The aerial part of Werneriaciliolata afforded a series of new diterpenes: two ent-kaurane derivatives, a nor-kaurane, an ent-manoyloxide derivative, a dimeric diterpene, as well as a rare diterpene. Their structures were elucidated by spectroscopic methods, including the concerted application of 1D NMR techniques (DEPT and NOEDS) and 2D NMR techniques (1H-1H COSY and HETCOR). In addition, four known kauranes, four coumarins and 6-hydroxytremetone were isolated. All isolated compounds from W. ciliolata and W. dactylophylla were tested in vitro for anti-viral activity against HIV-1, but only 6-hydroxytremetone showed a significant anti-HIV-1 activity

Constituents of Werneria ciliolata and their in vitro anti-hiv activity

PIACENTE, Sonia;AQUINO, Rita Patrizia;DE TOMMASI, Nunziatina;PIZZA, Cosimo;
1994

Abstract

Abstract: The aerial part of Werneriaciliolata afforded a series of new diterpenes: two ent-kaurane derivatives, a nor-kaurane, an ent-manoyloxide derivative, a dimeric diterpene, as well as a rare diterpene. Their structures were elucidated by spectroscopic methods, including the concerted application of 1D NMR techniques (DEPT and NOEDS) and 2D NMR techniques (1H-1H COSY and HETCOR). In addition, four known kauranes, four coumarins and 6-hydroxytremetone were isolated. All isolated compounds from W. ciliolata and W. dactylophylla were tested in vitro for anti-viral activity against HIV-1, but only 6-hydroxytremetone showed a significant anti-HIV-1 activity
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11386/3136846
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