Abstract: Sickingia williamsii Standl. (Rubiaceae) is used in Peruvian folk medicine for its analgesic and anti-inflammatory activity. In this study we have examined the pharmacological profiles of petroleum ether, chloroform, chloroform-methanol (9:1) and methanol extracts of the tree. Both chloroform-methanol (250, 500 or 750 mg kg−1, p.o.) and methanol (125, 250 or 500 mg kg−1, p.o.) extracts significantly reduced both the locomotor activity and motor co-ordination of mice; they also prolonged sleep induced by pentobarbital, although no significant cataleptic response was observed. These extracts did not have a significant impact on the nociceptive threshold in the hot-plate and tail-flick tests. Petroleum ether and chloroform extracts did not, furthermore, induce any significant pharmacological effects.The results of the study suggest that these extracts possess neurosedative-like properties.
Neuropharmacological Effects of Extracts from Sickingia williamsii
CAPASSO, Anna;AQUINO, Rita Patrizia;DE SIMONE, Francesco;
1996
Abstract
Abstract: Sickingia williamsii Standl. (Rubiaceae) is used in Peruvian folk medicine for its analgesic and anti-inflammatory activity. In this study we have examined the pharmacological profiles of petroleum ether, chloroform, chloroform-methanol (9:1) and methanol extracts of the tree. Both chloroform-methanol (250, 500 or 750 mg kg−1, p.o.) and methanol (125, 250 or 500 mg kg−1, p.o.) extracts significantly reduced both the locomotor activity and motor co-ordination of mice; they also prolonged sleep induced by pentobarbital, although no significant cataleptic response was observed. These extracts did not have a significant impact on the nociceptive threshold in the hot-plate and tail-flick tests. Petroleum ether and chloroform extracts did not, furthermore, induce any significant pharmacological effects.The results of the study suggest that these extracts possess neurosedative-like properties.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.