Abstract: Sickingia williamsii Standl. (Rubiaceae) is used in Peruvian folk medicine for its analgesic and anti-inflammatory activity. In this study we have examined the pharmacological profiles of petroleum ether, chloroform, chloroform-methanol (9:1) and methanol extracts of the tree. Both chloroform-methanol (250, 500 or 750 mg kg−1, p.o.) and methanol (125, 250 or 500 mg kg−1, p.o.) extracts significantly reduced both the locomotor activity and motor co-ordination of mice; they also prolonged sleep induced by pentobarbital, although no significant cataleptic response was observed. These extracts did not have a significant impact on the nociceptive threshold in the hot-plate and tail-flick tests. Petroleum ether and chloroform extracts did not, furthermore, induce any significant pharmacological effects.The results of the study suggest that these extracts possess neurosedative-like properties.

Neuropharmacological Effects of Extracts from Sickingia williamsii

CAPASSO, Anna;AQUINO, Rita Patrizia;DE SIMONE, Francesco;
1996

Abstract

Abstract: Sickingia williamsii Standl. (Rubiaceae) is used in Peruvian folk medicine for its analgesic and anti-inflammatory activity. In this study we have examined the pharmacological profiles of petroleum ether, chloroform, chloroform-methanol (9:1) and methanol extracts of the tree. Both chloroform-methanol (250, 500 or 750 mg kg−1, p.o.) and methanol (125, 250 or 500 mg kg−1, p.o.) extracts significantly reduced both the locomotor activity and motor co-ordination of mice; they also prolonged sleep induced by pentobarbital, although no significant cataleptic response was observed. These extracts did not have a significant impact on the nociceptive threshold in the hot-plate and tail-flick tests. Petroleum ether and chloroform extracts did not, furthermore, induce any significant pharmacological effects.The results of the study suggest that these extracts possess neurosedative-like properties.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11386/3137350
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