Abstract: The effect of indole alkaloids from Sickingia williamsii Standi. (Rubiaceae) on the effects of morphine withdrawal have been examined in-vitro. All the indole alkaloids isolated from S. williamsii (10−4, 5 ×10−5 and 10−5m) significantly and in a concentration-dependent manner reduced the effects of morphine withdrawal on the guinea-pig ileum. The results suggest that these alkaloids might be potential anti-addictive agents.
Indole Alkaloids from Sickingia williamsii Reduce the In-vitro Effects of Morphine Withdrawal in the Guinea-pig
CAPASSO, Anna;AQUINO, Rita Patrizia;DE SIMONE, Francesco;
1997-01-01
Abstract
Abstract: The effect of indole alkaloids from Sickingia williamsii Standi. (Rubiaceae) on the effects of morphine withdrawal have been examined in-vitro. All the indole alkaloids isolated from S. williamsii (10−4, 5 ×10−5 and 10−5m) significantly and in a concentration-dependent manner reduced the effects of morphine withdrawal on the guinea-pig ileum. The results suggest that these alkaloids might be potential anti-addictive agents.File in questo prodotto:
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