A dramatic enhancement of the diastereo- and enantioselectivity in the nitro-Michael addition reaction organocatalysed by a commercially available a,a-L-diaryl prolinol was disclosed when performing the reaction in unconventional hexafluorobenzene as a medium. DFT calculations were performed to clarify the origin of stereoselectivity and the role of C6F6.

Hexafluorobenzene: apowerful solvent for a noncovalent stereoselective organocatalytic Michael addition reaction

LATTANZI, Alessandra;DE FUSCO, CLAUDIA;RUSSO, ALESSIO;CAVALLO, LUIGI
2012

Abstract

A dramatic enhancement of the diastereo- and enantioselectivity in the nitro-Michael addition reaction organocatalysed by a commercially available a,a-L-diaryl prolinol was disclosed when performing the reaction in unconventional hexafluorobenzene as a medium. DFT calculations were performed to clarify the origin of stereoselectivity and the role of C6F6.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11386/3137390
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