A dramatic enhancement of the diastereo- and enantioselectivity in the nitro-Michael addition reaction organocatalysed by a commercially available a,a-L-diaryl prolinol was disclosed when performing the reaction in unconventional hexafluorobenzene as a medium. DFT calculations were performed to clarify the origin of stereoselectivity and the role of C6F6.
Hexafluorobenzene: apowerful solvent for a noncovalent stereoselective organocatalytic Michael addition reaction
LATTANZI, Alessandra;DE FUSCO, CLAUDIA;RUSSO, ALESSIO;CAVALLO, LUIGI
2012-01-01
Abstract
A dramatic enhancement of the diastereo- and enantioselectivity in the nitro-Michael addition reaction organocatalysed by a commercially available a,a-L-diaryl prolinol was disclosed when performing the reaction in unconventional hexafluorobenzene as a medium. DFT calculations were performed to clarify the origin of stereoselectivity and the role of C6F6.File in questo prodotto:
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