EuCl3 proves to be an efficient catalyst for Michael addn. of 1,3-dicarbonyl compds. Chiral complex Eu(tfc)3 [tfc = 3-(trifluoromethylhydroxymethylene)-d-camphorato] allows the formation of Michael adducts in an enantioselective way. Thus, treatment of MeCOCHEtCO2Et with 3-buten-2-one and Eu(tfc)3 in CCl4 afforded 71% MeCOCEt(CO2Et)CH2CH2COMe with 25% e.e.
Lanthanides in organic synthesis: Eu+3-catalyzed Michael addition of 1,3- dicarbonyl compounds
LATTANZI, Alessandra;SCETTRI, Arrigo
1993-01-01
Abstract
EuCl3 proves to be an efficient catalyst for Michael addn. of 1,3-dicarbonyl compds. Chiral complex Eu(tfc)3 [tfc = 3-(trifluoromethylhydroxymethylene)-d-camphorato] allows the formation of Michael adducts in an enantioselective way. Thus, treatment of MeCOCHEtCO2Et with 3-buten-2-one and Eu(tfc)3 in CCl4 afforded 71% MeCOCEt(CO2Et)CH2CH2COMe with 25% e.e.File in questo prodotto:
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