Abstract: The effects of extracts, partially purified fractions and four flavonol glycosides 1–4 from Aristeguietia discolor were investigated on the naloxone-precipitated withdrawal contraction of the acute morphine dependent guinea-pig ileum in vitro. After a 4 min in vitro exposure to morphine a strong contraction of guinea-pig isolated ileum was observed after the addition of naloxone. Both MeOH extract (50, 100 and 200 mg/mL), the partially purified fractions I, L, M and N (50, 100 and 200 mg/mL) and flavonol glycosides 1–4 (1 × 10−4 5 × 10−5 1 × 10−5 M), injected 10 min before morphine, were capable of blocking the naloxone-induced contraction after exposure to morphine in a concentration-dependent fashion.

Flavonol glycosides from Aristeguietia discolor reduce morphine withdrawal in vitro

CAPASSO, Anna;DE SIMONE, Francesco;AQUINO, Rita Patrizia
2000-01-01

Abstract

Abstract: The effects of extracts, partially purified fractions and four flavonol glycosides 1–4 from Aristeguietia discolor were investigated on the naloxone-precipitated withdrawal contraction of the acute morphine dependent guinea-pig ileum in vitro. After a 4 min in vitro exposure to morphine a strong contraction of guinea-pig isolated ileum was observed after the addition of naloxone. Both MeOH extract (50, 100 and 200 mg/mL), the partially purified fractions I, L, M and N (50, 100 and 200 mg/mL) and flavonol glycosides 1–4 (1 × 10−4 5 × 10−5 1 × 10−5 M), injected 10 min before morphine, were capable of blocking the naloxone-induced contraction after exposure to morphine in a concentration-dependent fashion.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11386/3137459
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