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EnglishThe effect of orgotein, the drug version of bovine Cu-Zn superoxide dismutase, on PG production by phagocytosing leukocytes has been investigated. Orgotein inhibited PG formation in a dose/dependent manner. Arachidonic acid was able to reverse this inhibitory effect. In the light of these results it is suggested that anti-inflammatory properties of orgotein may depend, at least in part, on the inhibition of phospholipase activation.
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http://hdl.handle.net/11386/3138642| Titolo: | Study on the effect of superoxide dismutase on arachidonic acid metabolism. |
| Autori interni: | PARENTE, Luca |
| Data di pubblicazione: | 1982 |
| Rivista: | PROSTAGLANDINS |
| Abstract: | The effect of orgotein, the drug version of bovine Cu-Zn superoxide dismutase, on PG production by phagocytosing leukocytes has been investigated. Orgotein inhibited PG formation in a dose/dependent manner. Arachidonic acid was able to reverse this inhibitory effect. In the light of these results it is suggested that anti-inflammatory properties of orgotein may depend, at least in part, on the inhibition of phospholipase activation. |
| Handle: | http://hdl.handle.net/11386/3138642 |
| Appare nelle tipologie: | 1.1.2 Articolo su rivista con ISSN |
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