As part of our screening of anti-AIDS agents from medicinal plants, the MeOH extract of the aerial parts of Ardisia japonica was tested, and it showed moderate in vitro anti-HIV activity. Reexamination to identify the compounds responsible for the anti-HIV activity revealed several known compounds and a new triterpenoid saponin (4) whose structure elucidation was accomplished by H-1-H-1 correlation spectroscopy (COSY, HOHAHA, POESY) and H-1-C-13 heteronuclear correlation (HETCOR) NMR experiments. All of the isolated compounds were tested and, although none of the triterpenoid saponins was active, bergenin and norbergenin showed weak anti-HIV activity.
Constituents Of Ardisia japonica and Their In Vitro Anti-HIV Activity
PIACENTE, Sonia;PIZZA, Cosimo;DE TOMMASI, Nunziatina;
1996
Abstract
As part of our screening of anti-AIDS agents from medicinal plants, the MeOH extract of the aerial parts of Ardisia japonica was tested, and it showed moderate in vitro anti-HIV activity. Reexamination to identify the compounds responsible for the anti-HIV activity revealed several known compounds and a new triterpenoid saponin (4) whose structure elucidation was accomplished by H-1-H-1 correlation spectroscopy (COSY, HOHAHA, POESY) and H-1-C-13 heteronuclear correlation (HETCOR) NMR experiments. All of the isolated compounds were tested and, although none of the triterpenoid saponins was active, bergenin and norbergenin showed weak anti-HIV activity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
