A convergent pathway is described for the synthesis of the marine macrolides aplyolides C 4 and E 5. The key fragment 8 was prepared stereo selectively by Sharpless asymmetric dihydroxylation of eneyne 13.
First total synthesis of natural aplyolides C and E, ichthyotoxic macrolides isolated from the skin of the marine mollusc Aplysia depilans
CARUSO, Tonino;
2002-01-01
Abstract
A convergent pathway is described for the synthesis of the marine macrolides aplyolides C 4 and E 5. The key fragment 8 was prepared stereo selectively by Sharpless asymmetric dihydroxylation of eneyne 13.File in questo prodotto:
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