In this article we describe a new accessible methodology for the synthesis of isobenzofuran-1(3H)-ones. In this process we exploited an effective, economic, useful and environmentally benign K2CO3 catalyzed, solvent-free one-pot tandemaldol-lactonization reaction between activemethylene compounds andmethyl 2-carboxy benzaldehyde. A particularly simple work-up and purification procedure are additional advantages addressed to a general green chemistry approach to this important class of heterocyclic compounds.

Active methylene compounds in a very effective approach to 3-substitutedisobenzofuranones through tandem aldol/lactonization reactions

DE CAPRARIIS, Paolo;FILOSA, Rosanna;MASSA, Antonio
2012

Abstract

In this article we describe a new accessible methodology for the synthesis of isobenzofuran-1(3H)-ones. In this process we exploited an effective, economic, useful and environmentally benign K2CO3 catalyzed, solvent-free one-pot tandemaldol-lactonization reaction between activemethylene compounds andmethyl 2-carboxy benzaldehyde. A particularly simple work-up and purification procedure are additional advantages addressed to a general green chemistry approach to this important class of heterocyclic compounds.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11386/3308877
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