Exhaled nitric oxide (eNO) is increasingly used as a marker of disease activity in asthma. Inhaled hypertonic saline has been shown to induce bronchoconstriction and to decrease eNOin asthmatic subjects, whereas the effects of hypotonic solutions on eNOin these patients have not been studied. To evaluate the effect of ultrasonically nebulized distilled water (UNDW), an indirect hypotonic stimulus, on eNO, 17 asthmatic patients were enrolled and eNOfrom lower airways was measured by chemiluminescence. UNDW significantly reduced FEV1 ‡ 20% in 9 subjects (UNDW+), but had no effect in eight patients (UNDW)). Baseline eNOconcentra tion were found to be 51.3 ± 11.1 ppb in UNDW+ and 32.9 ± 7.5 ppb in UNDW) patients, respectively (p = 0.199, NS). UNDW inhalation significantly decreased eNO (from 51.3 ± 11.1 ppb to 31.0 ± 7.1 ppb in UNDW+ (p<0.020, n = 9) and from 32.9 ± 7.5 ppb to 26.2 ± 7.3 ppb in UNDW) subjects (p<0.024, n = 8), respectively). eNOpe rcentage reduction in UNDW+ patients was significantly higher compared with UNDW) subjects ()37 ± 4% vs )23 ± 3%, p = 0.021). There was no correlation between FEV1 changes and eNOpercent age decreases in both UNDW+ and UNDW) subjects. In UNDW+ patients, acute bronchodilation induced by salbutamol caused a recovery in both FEV1 and eNO, though eNO levels remained lower than baseline values. We concluded that UNDW inhalation can significantly decrease eNOin asthmatic patients, either responders or nonresponders to this indirect osmotic challenge; the reduction in eNOlevel s was only partly dependent on acute changes in airway caliber.
Inhaled ultrasonically nebulized distilled water decreases exhaled nitric oxide in asthma.
VATRELLA, Alessandro;
2002-01-01
Abstract
Exhaled nitric oxide (eNO) is increasingly used as a marker of disease activity in asthma. Inhaled hypertonic saline has been shown to induce bronchoconstriction and to decrease eNOin asthmatic subjects, whereas the effects of hypotonic solutions on eNOin these patients have not been studied. To evaluate the effect of ultrasonically nebulized distilled water (UNDW), an indirect hypotonic stimulus, on eNO, 17 asthmatic patients were enrolled and eNOfrom lower airways was measured by chemiluminescence. UNDW significantly reduced FEV1 ‡ 20% in 9 subjects (UNDW+), but had no effect in eight patients (UNDW)). Baseline eNOconcentra tion were found to be 51.3 ± 11.1 ppb in UNDW+ and 32.9 ± 7.5 ppb in UNDW) patients, respectively (p = 0.199, NS). UNDW inhalation significantly decreased eNO (from 51.3 ± 11.1 ppb to 31.0 ± 7.1 ppb in UNDW+ (p<0.020, n = 9) and from 32.9 ± 7.5 ppb to 26.2 ± 7.3 ppb in UNDW) subjects (p<0.024, n = 8), respectively). eNOpe rcentage reduction in UNDW+ patients was significantly higher compared with UNDW) subjects ()37 ± 4% vs )23 ± 3%, p = 0.021). There was no correlation between FEV1 changes and eNOpercent age decreases in both UNDW+ and UNDW) subjects. In UNDW+ patients, acute bronchodilation induced by salbutamol caused a recovery in both FEV1 and eNO, though eNO levels remained lower than baseline values. We concluded that UNDW inhalation can significantly decrease eNOin asthmatic patients, either responders or nonresponders to this indirect osmotic challenge; the reduction in eNOlevel s was only partly dependent on acute changes in airway caliber.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
