A tandem aldol–heterocyclization–rearrangement reaction and one-pot sequential Michael addition allowed a direct access to highly functionalized 3-isoindolinones containing quaternary carbon centers. The desired products are obtained under mild conditions and in short reaction times by galvanostatic electrolysis in a divided cell. A further tandem intramolecular heterocyclization reaction leading to synthetically relevant hemiaminal derivatives has been established with suitable Michael acceptors.

Electrochemically initiated tandem and sequential conjugate addition processes: one-pot synthesis of diverse functionalized isoindolinones

PALOMBI, Laura;DI MOLA, ANTONIA;MASSA, Antonio
2012

Abstract

A tandem aldol–heterocyclization–rearrangement reaction and one-pot sequential Michael addition allowed a direct access to highly functionalized 3-isoindolinones containing quaternary carbon centers. The desired products are obtained under mild conditions and in short reaction times by galvanostatic electrolysis in a divided cell. A further tandem intramolecular heterocyclization reaction leading to synthetically relevant hemiaminal derivatives has been established with suitable Michael acceptors.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11386/3863685
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