A tandem aldol–heterocyclization–rearrangement reaction and one-pot sequential Michael addition allowed a direct access to highly functionalized 3-isoindolinones containing quaternary carbon centers. The desired products are obtained under mild conditions and in short reaction times by galvanostatic electrolysis in a divided cell. A further tandem intramolecular heterocyclization reaction leading to synthetically relevant hemiaminal derivatives has been established with suitable Michael acceptors.
Electrochemically initiated tandem and sequential conjugate addition processes: one-pot synthesis of diverse functionalized isoindolinones
PALOMBI, Laura;DI MOLA, ANTONIA;MASSA, Antonio
2012-01-01
Abstract
A tandem aldol–heterocyclization–rearrangement reaction and one-pot sequential Michael addition allowed a direct access to highly functionalized 3-isoindolinones containing quaternary carbon centers. The desired products are obtained under mild conditions and in short reaction times by galvanostatic electrolysis in a divided cell. A further tandem intramolecular heterocyclization reaction leading to synthetically relevant hemiaminal derivatives has been established with suitable Michael acceptors.File in questo prodotto:
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