Bronchodilator, vasodilator and spasmolytic activities of methanolic extract of Myrtus communis L

Janbaz, K. H.; Nisa, M.; Saqib, F.; Imran, I.; Zia-ul-haq, M.; De Feo, V.

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The present study was undertaken to validate some of the folkloric claims about the effectiveness of the use of a Myrtus communis L. crude methanol extract (Mc.Cr) in gastrointestinal, respiratory and vascular diseases. Mc.Cr caused complete relaxation of spontaneous and K+ (80 mM)-induced contractions in isolated rabbit jejunum. It caused right ward parallel shift of calcium concentration response curves. Mc.Cr exhibited relaxant effect on CCh- and K+ (80 mM)- induced contractions in isolated rabbit tracheal preparations. Furthermore, Mc.Cr caused relaxation of phenylephrine (1 μM)- and K+ (80 mM)-induced contractions in isolated rabbit aorta preparations. These effects were similar to verapamil, a standard calcium channel blocker. These findings could be the basis for explaining the spasmolytic, bronchodilator and vasodilator activities of the extract, through a possible calcium channel blocking activity.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11386/4240068

Titolo:	Bronchodilator, vasodilator and spasmolytic activities of methanolic extract of Myrtus communis L
Autori interni:	DE FEO, Vincenzo
Data di pubblicazione:	2013
Rivista:	JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
Abstract:	The present study was undertaken to validate some of the folkloric claims about the effectiveness of the use of a Myrtus communis L. crude methanol extract (Mc.Cr) in gastrointestinal, respiratory and vascular diseases. Mc.Cr caused complete relaxation of spontaneous and K+ (80 mM)-induced contractions in isolated rabbit jejunum. It caused right ward parallel shift of calcium concentration response curves. Mc.Cr exhibited relaxant effect on CCh- and K+ (80 mM)- induced contractions in isolated rabbit tracheal preparations. Furthermore, Mc.Cr caused relaxation of phenylephrine (1 μM)- and K+ (80 mM)-induced contractions in isolated rabbit aorta preparations. These effects were similar to verapamil, a standard calcium channel blocker. These findings could be the basis for explaining the spasmolytic, bronchodilator and vasodilator activities of the extract, through a possible calcium channel blocking activity.
Handle:	http://hdl.handle.net/11386/4240068
Appare nelle tipologie:	1.1.2 Articolo su rivista con ISSN

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