The synthesis and characterization of some new titanocene-complexes, having a ethenyl-phenoxide or a benzyl group as substituents of the cyclopentadienyl rings, are reported. The synthesized compounds have been evaluated for their cytotoxic potential against two human breast cancer cell lines, that is: MCF7 and SkBr3. Most of these compounds have shown significant cytotoxic effects, compared to cisplatin, in MTT-based cell tests.
|Titolo:||New titanocene derivatives with high antiproliferative activity against breast cancer cells|
|Autori interni:||SATURNINO, Carmela|
|Data di pubblicazione:||2014|
|Rivista:||BIOORGANIC & MEDICINAL CHEMISTRY LETTERS|
|Appare nelle tipologie:||1.1.1 Articolo su rivista con DOI|