Morphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: the pink–parkin pathway

Giuseppina, Amadoro; Veronica, Corsetti; Fulvio, Florenzano; Anna, Atlante; Antonella, Bobba; Vanessa, Nicolin; Nori, Stefania Lucia; Pietro, Calissano

doi:10.3389/fnagi.2014.00018

Evidencesuggestsastrikingcausalrelationshipbetweenchangesinqualitycontrolofneuronalmitochondriaandnumerousdevastatinghumanneurodegenerativediseases,includingParkinson’sdisease,Alzheimer’sdisease,Huntington’sdisease,andamyotrophiclateralsclerosis.Contrarytoreplicatingmammaliancellswithametabolismessentiallyglycolytic,post-mitoticneuronsaredistinctiveowingto(i)theirexclusiveenergeticdependencefrommitochondrialmetabolismand(ii)theirpolarizedshape,whichentailscompartmentalizedanddistinctenergeticneeds.Here,wereviewtherecentfindingsonmitochondrialdynamicsandmitophagyindifferentiatedneuronsfocusingonhowtheexceptionalcharacteristicsofneuronalpopulationsintheirmorphologyandbioenergeticsneedsmakethemquitedifferenttoothercellsincontrollingtheintracellularturnoveroftheseorganelles.

Titolo:	Morphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: the pink–parkin pathway
Autori:	Giuseppina Amadoro Veronica Corsetti Fulvio Florenzano Anna Atlante Antonella Bobba Vanessa Nicolin NORI, Stefania Lucia Pietro Calissano mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2014
Rivista:	FRONTIERS IN AGING NEUROSCIENCE
Abstract:	Evidencesuggestsastrikingcausalrelationshipbetweenchangesinqualitycontrolofneuronalmitochondriaandnumerousdevastatinghumanneurodegenerativediseases,includingParkinson’sdisease,Alzheimer’sdisease,Huntington’sdisease,andamyotrophiclateralsclerosis.Contrarytoreplicatingmammaliancellswithametabolismessentiallyglycolytic,post-mitoticneuronsaredistinctiveowingto(i)theirexclusiveenergeticdependencefrommitochondrialmetabolismand(ii)theirpolarizedshape,whichentailscompartmentalizedanddistinctenergeticneeds.Here,wereviewtherecentfindingsonmitochondrialdynamicsandmitophagyindifferentiatedneuronsfocusingonhowtheexceptionalcharacteristicsofneuronalpopulationsintheirmorphologyandbioenergeticsneedsmakethemquitedifferenttoothercellsincontrollingtheintracellularturnoveroftheseorganelles.
Handle:	http://hdl.handle.net/11386/4283453
Appare nelle tipologie:	1.1.1 Articolo su rivista con DOI

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