Evidencesuggestsastrikingcausalrelationshipbetweenchangesinqualitycontrolofneuronalmitochondriaandnumerousdevastatinghumanneurodegenerativediseases,includingParkinson’sdisease,Alzheimer’sdisease,Huntington’sdisease,andamyotrophiclateralsclerosis.Contrarytoreplicatingmammaliancellswithametabolismessentiallyglycolytic,post-mitoticneuronsaredistinctiveowingto(i)theirexclusiveenergeticdependencefrommitochondrialmetabolismand(ii)theirpolarizedshape,whichentailscompartmentalizedanddistinctenergeticneeds.Here,wereviewtherecentfindingsonmitochondrialdynamicsandmitophagyindifferentiatedneuronsfocusingonhowtheexceptionalcharacteristicsofneuronalpopulationsintheirmorphologyandbioenergeticsneedsmakethemquitedifferenttoothercellsincontrollingtheintracellularturnoveroftheseorganelles.
Morphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: the pink–parkin pathway
NORI, Stefania Lucia;
2014
Abstract
Evidencesuggestsastrikingcausalrelationshipbetweenchangesinqualitycontrolofneuronalmitochondriaandnumerousdevastatinghumanneurodegenerativediseases,includingParkinson’sdisease,Alzheimer’sdisease,Huntington’sdisease,andamyotrophiclateralsclerosis.Contrarytoreplicatingmammaliancellswithametabolismessentiallyglycolytic,post-mitoticneuronsaredistinctiveowingto(i)theirexclusiveenergeticdependencefrommitochondrialmetabolismand(ii)theirpolarizedshape,whichentailscompartmentalizedanddistinctenergeticneeds.Here,wereviewtherecentfindingsonmitochondrialdynamicsandmitophagyindifferentiatedneuronsfocusingonhowtheexceptionalcharacteristicsofneuronalpopulationsintheirmorphologyandbioenergeticsneedsmakethemquitedifferenttoothercellsincontrollingtheintracellularturnoveroftheseorganelles.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
