Evidencesuggestsastrikingcausalrelationshipbetweenchangesinqualitycontrolofneuronalmitochondriaandnumerousdevastatinghumanneurodegenerativediseases,includingParkinson’sdisease,Alzheimer’sdisease,Huntington’sdisease,andamyotrophiclateralsclerosis.Contrarytoreplicatingmammaliancellswithametabolismessentiallyglycolytic,post-mitoticneuronsaredistinctiveowingto(i)theirexclusiveenergeticdependencefrommitochondrialmetabolismand(ii)theirpolarizedshape,whichentailscompartmentalizedanddistinctenergeticneeds.Here,wereviewtherecentfindingsonmitochondrialdynamicsandmitophagyindifferentiatedneuronsfocusingonhowtheexceptionalcharacteristicsofneuronalpopulationsintheirmorphologyandbioenergeticsneedsmakethemquitedifferenttoothercellsincontrollingtheintracellularturnoveroftheseorganelles.

Morphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: the pink–parkin pathway

NORI, Stefania Lucia;
2014

Abstract

Evidencesuggestsastrikingcausalrelationshipbetweenchangesinqualitycontrolofneuronalmitochondriaandnumerousdevastatinghumanneurodegenerativediseases,includingParkinson’sdisease,Alzheimer’sdisease,Huntington’sdisease,andamyotrophiclateralsclerosis.Contrarytoreplicatingmammaliancellswithametabolismessentiallyglycolytic,post-mitoticneuronsaredistinctiveowingto(i)theirexclusiveenergeticdependencefrommitochondrialmetabolismand(ii)theirpolarizedshape,whichentailscompartmentalizedanddistinctenergeticneeds.Here,wereviewtherecentfindingsonmitochondrialdynamicsandmitophagyindifferentiatedneuronsfocusingonhowtheexceptionalcharacteristicsofneuronalpopulationsintheirmorphologyandbioenergeticsneedsmakethemquitedifferenttoothercellsincontrollingtheintracellularturnoveroftheseorganelles.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11386/4283453
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