Evidencesuggestsastrikingcausalrelationshipbetweenchangesinqualitycontrolofneuronalmitochondriaandnumerousdevastatinghumanneurodegenerativediseases,includingParkinson’sdisease,Alzheimer’sdisease,Huntington’sdisease,andamyotrophiclateralsclerosis.Contrarytoreplicatingmammaliancellswithametabolismessentiallyglycolytic,post-mitoticneuronsaredistinctiveowingto(i)theirexclusiveenergeticdependencefrommitochondrialmetabolismand(ii)theirpolarizedshape,whichentailscompartmentalizedanddistinctenergeticneeds.Here,wereviewtherecentfindingsonmitochondrialdynamicsandmitophagyindifferentiatedneuronsfocusingonhowtheexceptionalcharacteristicsofneuronalpopulationsintheirmorphologyandbioenergeticsneedsmakethemquitedifferenttoothercellsincontrollingtheintracellularturnoveroftheseorganelles.
Titolo: | Morphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: the pink–parkin pathway | |
Autori: | ||
Data di pubblicazione: | 2014 | |
Rivista: | ||
Abstract: | Evidencesuggestsastrikingcausalrelationshipbetweenchangesinqualitycontrolofneuronalmitochondriaandnumerousdevastatinghumanneurodegenerativediseases,includingParkinson’sdisease,Alzheimer’sdisease,Huntington’sdisease,andamyotrophiclateralsclerosis.Contrarytoreplicatingmammaliancellswithametabolismessentiallyglycolytic,post-mitoticneuronsaredistinctiveowingto(i)theirexclusiveenergeticdependencefrommitochondrialmetabolismand(ii)theirpolarizedshape,whichentailscompartmentalizedanddistinctenergeticneeds.Here,wereviewtherecentfindingsonmitochondrialdynamicsandmitophagyindifferentiatedneuronsfocusingonhowtheexceptionalcharacteristicsofneuronalpopulationsintheirmorphologyandbioenergeticsneedsmakethemquitedifferenttoothercellsincontrollingtheintracellularturnoveroftheseorganelles. | |
Handle: | http://hdl.handle.net/11386/4283453 | |
Appare nelle tipologie: | 1.1.1 Articolo su rivista con DOI |