Androstanes and pregnanes from Trichilia emetica ssp. suberosa J.J. de Wilde

Malafronte, Nicola; Rokia, Sanogo; Antonio, Vassallo; De Tommasi, Nunziatina; Bifulco, Giuseppe; Dal Piaz, Fabrizio

doi:10.1016/j.phytochem.2013.09.019

Four pregnanes: 1-methoxy-pregnan-17(R)-1,4-dien-3,16-dione (1), 1-methoxy-pregnan-17(S)-1,4-dien-3,16-dione (2), 2,3-seco-pregnan-17(S)-2,3-dioic acid-16-oxo-dimethyl ester (4), 2α,3α,16α-trihydroxy-5α-pregnan-17(R)-20-yl acetate (7), three androstanes: 1-methoxy-androstan-1,4-dien-3,16-dione (3), 2,3-seco-androstan-2,3-dioic acid-16-oxo-dimethyl ester (5), 3-methoxycarbonyl-2,3-seco-androstan-3-oic acid-16-oxo-2,19-lactone (6), together with three known pregnane derivatives, were isolated from the roots of Trichilia emetica ssp. suberosa. Their structures were determined by means of 1D and 2D NMR spectroscopy, mass spectrometry analysis, as well as by quantum chemical calculations.

Titolo:	Androstanes and pregnanes from Trichilia emetica ssp. suberosa J.J. de Wilde
Autori:	MALAFRONTE, NICOLA Rokia Sanogo Antonio Vassallo DE TOMMASI, Nunziatina BIFULCO, Giuseppe DAL PIAZ, Fabrizio mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2013
Rivista:	PHYTOCHEMISTRY
Abstract:	Four pregnanes: 1-methoxy-pregnan-17(R)-1,4-dien-3,16-dione (1), 1-methoxy-pregnan-17(S)-1,4-dien-3,16-dione (2), 2,3-seco-pregnan-17(S)-2,3-dioic acid-16-oxo-dimethyl ester (4), 2α,3α,16α-trihydroxy-5α-pregnan-17(R)-20-yl acetate (7), three androstanes: 1-methoxy-androstan-1,4-dien-3,16-dione (3), 2,3-seco-androstan-2,3-dioic acid-16-oxo-dimethyl ester (5), 3-methoxycarbonyl-2,3-seco-androstan-3-oic acid-16-oxo-2,19-lactone (6), together with three known pregnane derivatives, were isolated from the roots of Trichilia emetica ssp. suberosa. Their structures were determined by means of 1D and 2D NMR spectroscopy, mass spectrometry analysis, as well as by quantum chemical calculations.
Handle:	http://hdl.handle.net/11386/4356253
Appare nelle tipologie:	1.1.1 Articolo su rivista con DOI

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