A bio-orthogonal click-chemistry procedure was developed to allow the in cell interactome profiling of scalaradial, an anti-inflammatory marine natural product. The results were validated through the application of the classical in vitro chemical proteomics and several bio-physical methods; peroxiredoxins, 14-3-3 isoforms and proteasomes were recognized as main scalaradial targets
In cell scalaradial interactome profiling using a bio-orthogonal clickable probe
CASSIANO, CHIARA;MARGARUCCI, LUIGI;ESPOSITO, ROBERTA;RICCIO, Raffaele;TOSCO, ALESSANDRA;CASAPULLO, Agostino;MONTI, Maria Chiara
2014
Abstract
A bio-orthogonal click-chemistry procedure was developed to allow the in cell interactome profiling of scalaradial, an anti-inflammatory marine natural product. The results were validated through the application of the classical in vitro chemical proteomics and several bio-physical methods; peroxiredoxins, 14-3-3 isoforms and proteasomes were recognized as main scalaradial targetsFile in questo prodotto:
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