The use of hydrogels in the preparation of controlled release pharmaceutical forms is extensively diffused.The main feature of these polymers is their ability to swell forming a gel layer when they enter in contactwith fluids. Once the gel layer is formed, the drug contained in the matrix can easily diffuse ensuring acontrolled release from the tablet. Measurement of water content within a hydrating matrix based onhydrogels is a key topic in the study of pharmaceutical solid dosage forms. The aim of this work is toevaluate the water content of swollen matrices composed by HPMC and theophylline both in axial and inradial direction, as a function of time, using a texture analysis. A relationship between water content andslope of the force–penetration curves has been obtained using a simplified system in which the wateruptake is allowed only in radial direction, obtaining thus partially hydrated matrices with the watercontent varying only along the radial direction. Once the relationship has been validated, it has beenapplied in a more complex system in which the polymer swelling takes place in both axial and radialdirection. Thus, using the texture analysis it has been possible to determine the water in each positionwithin the hydrated matrices.

Measurements of non-uniform water content inhydroxypropyl-methyl-cellulose based matrices via texture analysis

CASCONE, SARA;LAMBERTI, Gaetano;TITOMANLIO, Giuseppe;D'AMORE, Matteo;BARBA, Anna Angela
2014-01-01

Abstract

The use of hydrogels in the preparation of controlled release pharmaceutical forms is extensively diffused.The main feature of these polymers is their ability to swell forming a gel layer when they enter in contactwith fluids. Once the gel layer is formed, the drug contained in the matrix can easily diffuse ensuring acontrolled release from the tablet. Measurement of water content within a hydrating matrix based onhydrogels is a key topic in the study of pharmaceutical solid dosage forms. The aim of this work is toevaluate the water content of swollen matrices composed by HPMC and theophylline both in axial and inradial direction, as a function of time, using a texture analysis. A relationship between water content andslope of the force–penetration curves has been obtained using a simplified system in which the wateruptake is allowed only in radial direction, obtaining thus partially hydrated matrices with the watercontent varying only along the radial direction. Once the relationship has been validated, it has beenapplied in a more complex system in which the polymer swelling takes place in both axial and radialdirection. Thus, using the texture analysis it has been possible to determine the water in each positionwithin the hydrated matrices.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11386/4378454
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