Microencapsulation is a process providing the formation of thin coating around core structures, at solid, liquid or gas state, to stabilize them, to mask undesired taste or to modify release properties (Venkatesan et al., 2009). New approaches to microencapsulation process, especially in pharmaceutical products manufacturing, are continuously investigated with the aim to answer to several needs, basically avoiding inactivation of active molecules, reducing residual level of organic solvent and especially assuring the usefulness at industrial scale (Benita, 2006). For example, the development of shell-core systems by a coaxial atomizer may offer several additional advantages in drug delivery, such as delayed or pulsatile release and removal of drug ‘‘burst’’. Moreover, the coupling of ultrasonic source with coaxial atomization device could be of great interest thanks to ultrasonic atomization advantages: drops velocity 1-10% larger than of a hydraulic or air-atomizing nozzle, lower mechanical stress caused by vibration, avoided deactivation of bioactive substances and operation at low energy levels (Rajan, 2001). In this work shell-core particles were produced using a novel apparatus composed by a coaxial double channel device connected to a ultrasonic generator. Shell-core beads were produced to observe encapsulation process (with ultrasounds switched off) and preliminary steps towards shell-core microparticles production were performed.
SHELL-CORE PARTICLES PRODUCTION BY COAXIAL DOUBLE CHANNEL DEVICE
DALMORO, ANNALISA;D'AMORE, Matteo;BARBA, Anna Angela
2012-01-01
Abstract
Microencapsulation is a process providing the formation of thin coating around core structures, at solid, liquid or gas state, to stabilize them, to mask undesired taste or to modify release properties (Venkatesan et al., 2009). New approaches to microencapsulation process, especially in pharmaceutical products manufacturing, are continuously investigated with the aim to answer to several needs, basically avoiding inactivation of active molecules, reducing residual level of organic solvent and especially assuring the usefulness at industrial scale (Benita, 2006). For example, the development of shell-core systems by a coaxial atomizer may offer several additional advantages in drug delivery, such as delayed or pulsatile release and removal of drug ‘‘burst’’. Moreover, the coupling of ultrasonic source with coaxial atomization device could be of great interest thanks to ultrasonic atomization advantages: drops velocity 1-10% larger than of a hydraulic or air-atomizing nozzle, lower mechanical stress caused by vibration, avoided deactivation of bioactive substances and operation at low energy levels (Rajan, 2001). In this work shell-core particles were produced using a novel apparatus composed by a coaxial double channel device connected to a ultrasonic generator. Shell-core beads were produced to observe encapsulation process (with ultrasounds switched off) and preliminary steps towards shell-core microparticles production were performed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
