Four new clerodane diterpenes (1-4) and one new phenylpropanoid (5) have been isolated from Clerodendrum splendens aerial parts, together with nine known compounds. Their structures were determined by spectroscopic and spectrometric analysis and chemical methods. The absolute configuration of the 15,16-diol moiety in 4 was determined by Snatzkes method. Antiproliferative activity of diterpenes in HeLa cells was also evaluated. The IC50 values were 98 +/- 11 mu M for 3 and 101 +/- 8 mu M for 1, respectively.
Diterpenes and Phenylpropanoids from Clerodendrum splendens
COTUGNO, ROBERTA;DE TOMMASI, Nunziatina;
2013-01-01
Abstract
Four new clerodane diterpenes (1-4) and one new phenylpropanoid (5) have been isolated from Clerodendrum splendens aerial parts, together with nine known compounds. Their structures were determined by spectroscopic and spectrometric analysis and chemical methods. The absolute configuration of the 15,16-diol moiety in 4 was determined by Snatzkes method. Antiproliferative activity of diterpenes in HeLa cells was also evaluated. The IC50 values were 98 +/- 11 mu M for 3 and 101 +/- 8 mu M for 1, respectively.File in questo prodotto:
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