Some original chimeric structures formed by a hydroxamic acid moiety separated from a steroid nucleus (derived from cholanoic or abietic acids) by a seven atoms linker have been prepared and tested against the 11 HDAC isoforms. The products derived from abietic acid show promising results with a particular activity against Class IIb tubuline deaceyilating HDAC6.
STEROIDAL HYDROXAMIC ACID DERIVATIVES: A STRUCTURALLY NOVEL CLASS OF HDAC INHIBITORS
RANDINO, ROSARIO;RODRIQUEZ, Manuela
2014-01-01
Abstract
Some original chimeric structures formed by a hydroxamic acid moiety separated from a steroid nucleus (derived from cholanoic or abietic acids) by a seven atoms linker have been prepared and tested against the 11 HDAC isoforms. The products derived from abietic acid show promising results with a particular activity against Class IIb tubuline deaceyilating HDAC6.File in questo prodotto:
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