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EnglishAn alternative method for the synthesis of pseudopeptides containing a psi[CH2NH] amide bond surrogate is reported. The synthetic approach is based on a nucleophilic displacement of the chiral N-protected beta-iodoamines with conveniently protected amino acid esters. The compatibility of this method with both conventional and microwave-assisted peptide synthesis should increase the potentiality of the psi[CH2NH] peptide bond isostere in peptide chemistry.
http://hdl.handle.net/11386/4578318| Titolo: | Novel route in the synthesis of ψ[CH2NH] amide bond surrogate |
| Autori interni: | CAMPIGLIA, Pietro BERTAMINO, Alessia SALA, MARINA |
| Data di pubblicazione: | 2008 |
| Rivista: | TETRAHEDRON LETTERS |
| Abstract: | An alternative method for the synthesis of pseudopeptides containing a psi[CH2NH] amide bond surrogate is reported. The synthetic approach is based on a nucleophilic displacement of the chiral N-protected beta-iodoamines with conveniently protected amino acid esters. The compatibility of this method with both conventional and microwave-assisted peptide synthesis should increase the potentiality of the psi[CH2NH] peptide bond isostere in peptide chemistry. |
| Handle: | http://hdl.handle.net/11386/4578318 |
| Appare nelle tipologie: | 1.1.1 Articolo su rivista con DOI |
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