UniSa - IRIS Institutional Research Information System
IRIS è la soluzione IT che facilita la raccolta e la gestione dei dati relativi alle attività e ai prodotti della ricerca. Fornisce a ricercatori, amministratori e valutatori gli strumenti per monitorare i risultati della ricerca, aumentarne la visibilità e allocare in modo efficace le risorse disponibili.
EnglishAn alternative method for the synthesis of pseudopeptides containing a psi[CH2NH] amide bond surrogate is reported. The synthetic approach is based on a nucleophilic displacement of the chiral N-protected beta-iodoamines with conveniently protected amino acid esters. The compatibility of this method with both conventional and microwave-assisted peptide synthesis should increase the potentiality of the psi[CH2NH] peptide bond isostere in peptide chemistry.
| Titolo: | Novel route in the synthesis of ψ[CH2NH] amide bond surrogate | |
| Autori: | ||
| Data di pubblicazione: | 2008 | |
| Rivista: | ||
| Abstract: | An alternative method for the synthesis of pseudopeptides containing a psi[CH2NH] amide bond surrogate is reported. The synthetic approach is based on a nucleophilic displacement of the chiral N-protected beta-iodoamines with conveniently protected amino acid esters. The compatibility of this method with both conventional and microwave-assisted peptide synthesis should increase the potentiality of the psi[CH2NH] peptide bond isostere in peptide chemistry. | |
| Handle: | http://hdl.handle.net/11386/4578318 | |
| Appare nelle tipologie: | 1.1.1 Articolo su rivista con DOI |
File in questo prodotto:
http://hdl.handle.net/11386/4578318
Copyright © 2022