An alternative method for the synthesis of pseudopeptides containing a psi[CH2NH] amide bond surrogate is reported. The synthetic approach is based on a nucleophilic displacement of the chiral N-protected beta-iodoamines with conveniently protected amino acid esters. The compatibility of this method with both conventional and microwave-assisted peptide synthesis should increase the potentiality of the psi[CH2NH] peptide bond isostere in peptide chemistry.
Novel route in the synthesis of ψ[CH2NH] amide bond surrogate
CAMPIGLIA, Pietro;BERTAMINO, Alessia;SALA, MARINA;
2008-01-01
Abstract
An alternative method for the synthesis of pseudopeptides containing a psi[CH2NH] amide bond surrogate is reported. The synthetic approach is based on a nucleophilic displacement of the chiral N-protected beta-iodoamines with conveniently protected amino acid esters. The compatibility of this method with both conventional and microwave-assisted peptide synthesis should increase the potentiality of the psi[CH2NH] peptide bond isostere in peptide chemistry.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
