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EnglishIn the attempt to identify a new lead compound able to modify the conformational preferences of the beta-amyloid peptides, a set of new compounds characterized by a thiazolidine ring linked to several different aryl moieties were synthesized. The ability of these compounds to prevent the beta-amyloid aggregation was evaluated using circular dichroism and nuclear magnetic resonance techniques. Molecular docking procedure allowed an interpretation of spectroscopic in the key of molecular interaction.
| Titolo: | Conformational Stability of Aβ-(25-35) in the Presence of Thiazolidine Derivatives |
| Autori: | |
| Data di pubblicazione: | 2007 |
| Rivista: | |
| Abstract: | In the attempt to identify a new lead compound able to modify the conformational preferences of the beta-amyloid peptides, a set of new compounds characterized by a thiazolidine ring linked to several different aryl moieties were synthesized. The ability of these compounds to prevent the beta-amyloid aggregation was evaluated using circular dichroism and nuclear magnetic resonance techniques. Molecular docking procedure allowed an interpretation of spectroscopic in the key of molecular interaction. |
| Handle: | http://hdl.handle.net/11386/4578321 |
| Appare nelle tipologie: | 1.1.1 Articolo su rivista con DOI |
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