In the attempt to identify a new lead compound able to modify the conformational preferences of the beta-amyloid peptides, a set of new compounds characterized by a thiazolidine ring linked to several different aryl moieties were synthesized. The ability of these compounds to prevent the beta-amyloid aggregation was evaluated using circular dichroism and nuclear magnetic resonance techniques. Molecular docking procedure allowed an interpretation of spectroscopic in the key of molecular interaction.
Conformational Stability of Aβ-(25-35) in the Presence of Thiazolidine Derivatives
CAMPIGLIA, Pietro;BERTAMINO, Alessia;D'URSI, Anna Maria
2007-01-01
Abstract
In the attempt to identify a new lead compound able to modify the conformational preferences of the beta-amyloid peptides, a set of new compounds characterized by a thiazolidine ring linked to several different aryl moieties were synthesized. The ability of these compounds to prevent the beta-amyloid aggregation was evaluated using circular dichroism and nuclear magnetic resonance techniques. Molecular docking procedure allowed an interpretation of spectroscopic in the key of molecular interaction.File in questo prodotto:
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