The Baeyer–Villiger oxidation of cyclic ketones (I) to the corresponding lactones (II) can be improved using m-CPBA under microwave dielectric heating. A dramatic reduction of time—3 min compared to 5 days at room temperature—was observed to transform cycloheptanone into oxocan-2-one. X-Hydroxyalkyl hydroxamic acids (III), key intermediates for a rapid access to potent histone deacetylase inhibitors, are obtained in one-pot reaction of lactones using the Weinreb amidation.

Facile Baeyer–Villiger oxidation of cyclic ketones: conventional versus microwave-assisted approach

RANDINO, ROSARIO;D'URSI, Anna Maria;RODRIQUEZ, Manuela
2015-01-01

Abstract

The Baeyer–Villiger oxidation of cyclic ketones (I) to the corresponding lactones (II) can be improved using m-CPBA under microwave dielectric heating. A dramatic reduction of time—3 min compared to 5 days at room temperature—was observed to transform cycloheptanone into oxocan-2-one. X-Hydroxyalkyl hydroxamic acids (III), key intermediates for a rapid access to potent histone deacetylase inhibitors, are obtained in one-pot reaction of lactones using the Weinreb amidation.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11386/4650439
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