Catch a match: The best biomolecular partner for a given calixarene host can be found by fishing in a crude HeLa cellular extract. In particular, a simply designed pacetamidocalix[ 4]arene was able to specifically fish out protein disulfide isomerase (PDI). Independent studies confirmed its considerable affinity for PDI (KD=11 mm), the inhibition of PDI chaperone activity, and cytotoxic activity against two cancer cell lines
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