Activation of Ca2+/Calmodulin protein kinase II (CaMKII) is an important step in signaling of cardiac hypertrophy. The molecular mechanisms by which CaMKII integrates with other pathways in the heart are incompletely understood. We hypothesize that CaMKII association with extracellular regulated kinase (ERK), promotes cardiac hypertrophy through ERK nuclear localization.
Targeting the CaMKII/ERK Interaction in the Heart Prevents Cardiac Hypertrophy
CIPOLLETTA, ERSILIA;RUSCIANO, MARIA ROSARIA;CICCARELLI, Michele;CAMPIGLIA, Pietro;SALA, MARINA;IACCARINO, Guido;
2015-01-01
Abstract
Activation of Ca2+/Calmodulin protein kinase II (CaMKII) is an important step in signaling of cardiac hypertrophy. The molecular mechanisms by which CaMKII integrates with other pathways in the heart are incompletely understood. We hypothesize that CaMKII association with extracellular regulated kinase (ERK), promotes cardiac hypertrophy through ERK nuclear localization.File in questo prodotto:
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