In this Minireview recent advances in the asymmetric reactions of meso and racemic epoxides promoted by organocatalysts is reviewed. Organic promoters, such as chiral phosphoric acids, amino- and peptidyl thioureas, and sulfinamides, have been successfully used for a variety of enantioselective transformations of epoxides under catalytic conditions, involving direct nucleophilic attack at the oxirane ring, base-catalysed β-eliminations and Brønsted acid catalysed 1,2-rearrangements. Accordingly, highly valuable enantioenriched 1,2-functionalised alcohols, carbonyl compounds and nitroepoxides are attainable. Dual activation of the reagents, provided by the organocatalysts, appears to be the most recurrent strategy, potentially suitable to face other unmet challenges in asymmetric ring-opening reactions of epoxides.
|Titolo:||Organocatalytic Asymmetric Reactions of Epoxides: Recent Progress|
|Data di pubblicazione:||2016|
|Appare nelle tipologie:||1.1.2 Articolo su rivista con ISSN|