Interleukin-33 is a novel and an unconventional member of IL-1 family. It is an inflammation-induced factor with dual function exercising its role as an intracellular regulator of gene expression, as well as, an extracellular alarm mediator. It is a ligand for ST2, a heterodimeric membrane-bound receptor of the orphan IL-1 family receptor. Interleukin-33/ST2 signaling has been studied in a wide range of inflammatory skin conditions for its crucial role in immune responses and tissue homeostasis. In this review, we report the current knowledge regarding the complex biology of interleukin-33 and its function in the skin and in clinical settings.

Interleukin-33: increasing role in dermatological conditions

Raimondo, Annunziata;LEMBO, Serena
2016

Abstract

Interleukin-33 is a novel and an unconventional member of IL-1 family. It is an inflammation-induced factor with dual function exercising its role as an intracellular regulator of gene expression, as well as, an extracellular alarm mediator. It is a ligand for ST2, a heterodimeric membrane-bound receptor of the orphan IL-1 family receptor. Interleukin-33/ST2 signaling has been studied in a wide range of inflammatory skin conditions for its crucial role in immune responses and tissue homeostasis. In this review, we report the current knowledge regarding the complex biology of interleukin-33 and its function in the skin and in clinical settings.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11386/4675619
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