Mast cells and basophils (FcεRI+ cells) are classically involved in allergic disorders. HIV-1 glycoprotein gp 120 acts as a viral superantigen by interacting with the heavy chain, variable 3 (VH3) region of IgE to induce cytokine release from FcεRI+ cells. The chemokine receptors CCR3 and CXCR4, co-receptors for HIV-1, are expressed by FcεRI+ cells. Via its interaction with CCR3, HIV-1 transactivation (Tat) protein is a potent chemoattractant for FcεRI+ cells. Incubation of basophils with Tat protein upregulates the surface expression of the CCR3 receptor. There is some evidence that human FcεRI+ cells could be infected in vitro by M-tropic HIV-1 strains.
|Titolo:||Human mast cells and basophils in HIV-1 infection|
|Data di pubblicazione:||2001|
|Appare nelle tipologie:||1.1.1 Articolo su rivista con DOI|