Citral, 3,7-dimethyl-2,6-octadienal, is a key component of the essential oils extracted from several lemon-scented herbal plants. It has been demonstrated to be an effective antifungal agent and in recent years, to have antiproliferative effect in certain tumor cell lines: thus citral could be a potential anticancer drug. In this study, we investigated the effect of citral on the proliferation of pancreatic cell tumor lines (MIA PaCa-2 cells) and human Blymphoma (DeFew cells). To analyze which part of the molecule is pivotal for the activity, we also studied the effect of several citral related compounds, in particular focusing on some chemical aspects of the terpenic scaffold. The in vitro studies revealed the significant cytotoxic activity of some of the tested compounds.

Effect of citral and citral related compounds on viability of pancreatic and human B-lymphoma cell lines

DI MOLA, ANTONIA;MASSA, Antonio;DE FEO, Vincenzo;BASILE, ANNA;PASCALE, Maria;AQUINO, Rita Patrizia;DE CAPRARIIS, Paolo
2017

Abstract

Citral, 3,7-dimethyl-2,6-octadienal, is a key component of the essential oils extracted from several lemon-scented herbal plants. It has been demonstrated to be an effective antifungal agent and in recent years, to have antiproliferative effect in certain tumor cell lines: thus citral could be a potential anticancer drug. In this study, we investigated the effect of citral on the proliferation of pancreatic cell tumor lines (MIA PaCa-2 cells) and human Blymphoma (DeFew cells). To analyze which part of the molecule is pivotal for the activity, we also studied the effect of several citral related compounds, in particular focusing on some chemical aspects of the terpenic scaffold. The in vitro studies revealed the significant cytotoxic activity of some of the tested compounds.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11386/4682460
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 10
  • ???jsp.display-item.citation.isi??? 9
social impact