Nucleic acid based drugs (NABDs), powerful in principle, can be of great importance for health care applications if and only if effective delivery systems are available. Among NABDs, small interfering RNAs (siRNAs) show revolutionary potentiality due to the ability to silencing the expression of gene-causing diseases. Thus, siRNA drugs have huge therapeutic potentials, even in the treatment of life threatening diseases. However, the use of siRNAs is limited because of some inconveniences: they are large macromolecules, negatively charged, undergo rapid degradation by plasma enzymes, are subjected to fast renal clearance/hepatic sequestration and can hardly cross cellular membranes. These aspects seriously impair siRNAs usability as therapeutics. To overcome these obstacles, the scientific problem has to be faced out through a multidisciplinary approach, integrating all relevant and necessary expertise. In this Full-Thematic Issue of the Current Drug Delivery, the development of siRNAs delivery approaches is described from different points of view by several research groups, which have been jointly working on the subject in the last years.
|Titolo:||New Trends in Gene Therapy: Multidisciplinary Approaches to siRNAs Controlled Delivery|
|Data di pubblicazione:||2017|
|Appare nelle tipologie:||1.1.1 Articolo su rivista con DOI|