Enteric shell-core microparticles production by coupling ultrasonic atomization and polyelectrolytes complexation

Enteric shell-core microparticles, based on polyelectrolyte complexes between the natural biopolymer sodium alginate and the (meth)acrylate copolymers Eudragit®, were produced to encapsulate the gastrolesive drug indomethacin. The complexation of polyelectrolytes together with the ultrasonic atomization, used to produce fine droplets based on alginate ingredient, can be performed using mild conditions, aqueous solutions, in absence of organic solvents and chemical crosslinkers, therefore this approach proves to be convenient if compared to traditional methods