Ultrasonic assisted production of nanoliposomes as peptide delivery vectors

In this work, preparation and characterization of liposomal Small Unilamellar Vesicles (SUVs), loaded with a cationic peptide, purposely designed for cardiovascular diseases treatment, are presented. In particular, the attention has been focused on vesicles size and peptide load achievable by a protocol based on duty cycle sonication to form loaded SUVs starting from large vesicles. The applied technique gives the possibility to obtain liposomal vesicles-protecting peptides of tunable size according to the route of administration chosen for the delivery of peptide