The use of hydrogels in the development of pharmaceutical forms is widespread. The aim of this work is to describe the phenomena involved in the hydration of a hydrogel-based matrix. Gravimetric analyses have been used to describe the mass evolutions of water, drug, and polymer inside the matrix during the dissolution. Moreover, a texture analysis has been performed to quantify the water absorbed during the matrix dissolution. Finally, a mathematical model able to describe all the phenomena involved has been proposed and compared with the experimental results.
|Titolo:||Experimental and modeling description of hydrogel-based controlled release systems|
|Data di pubblicazione:||2016|
|Appare nelle tipologie:||4.1 Contributi in Atti di convegno|