Ultraviolet (UV) radiation exerts different harmful effects on human health, being the main etiological agent of certain skin cancers and photoaging. In this context, photoprotection, intended as a set of measures adopted to limit and prevent the effects of UV radiation, plays a critical role in avoiding undesired sunlight outcomes. Traditional sunscreens represent a widely used photoprotective approach, even if they exert a "passive photoprotection" and are not effective once damage to skin cells has been generated after sun exposure. Conversely, "active" photoprotection is represented by topical sunscreens including also antioxidants and liposome-containing DNA repair enzymes, which may constitute a photostrategy filling the current gap in sun protection. In the current review, we focused on "active" photoprotection at a topical level, reporting present knowledge and future prospective regarding DNA repair enzymes such as photolyase, endonuclease and 8-oxoguanine glycosylase which are able to enhance the protective power of traditional sunscreens.

"Active" photoprotection: Sunscreens with DNA repair enzymes

Lembo, Serena;
2017

Abstract

Ultraviolet (UV) radiation exerts different harmful effects on human health, being the main etiological agent of certain skin cancers and photoaging. In this context, photoprotection, intended as a set of measures adopted to limit and prevent the effects of UV radiation, plays a critical role in avoiding undesired sunlight outcomes. Traditional sunscreens represent a widely used photoprotective approach, even if they exert a "passive photoprotection" and are not effective once damage to skin cells has been generated after sun exposure. Conversely, "active" photoprotection is represented by topical sunscreens including also antioxidants and liposome-containing DNA repair enzymes, which may constitute a photostrategy filling the current gap in sun protection. In the current review, we focused on "active" photoprotection at a topical level, reporting present knowledge and future prospective regarding DNA repair enzymes such as photolyase, endonuclease and 8-oxoguanine glycosylase which are able to enhance the protective power of traditional sunscreens.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11386/4705038
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