The asymmetric Michael addition of aryl thiols and thioacetic acid to challenging β- or α,β-aryl substituted α,β-unsaturated N-acyl pyrazoles catalysed by bifunctional organocatalysts has been investigated. The corresponding sulfide derivatives are obtained under mild and simple conditions, using readily available amine-thioureas or squaramides with good to high stereocontrol (up to 89/11 dr and 98% ee).
Stereoselective organocatalytic sulfa-Michael reactions of aryl substituted α,β-unsaturated N-acyl pyrazoles
MENINNO, SARA
Supervision
;VARRICCHIO, LUCAMethodology
;Amedeo CapobiancoMembro del Collaboration Group
;Alessandra Lattanzi
Writing – Original Draft Preparation
2018
Abstract
The asymmetric Michael addition of aryl thiols and thioacetic acid to challenging β- or α,β-aryl substituted α,β-unsaturated N-acyl pyrazoles catalysed by bifunctional organocatalysts has been investigated. The corresponding sulfide derivatives are obtained under mild and simple conditions, using readily available amine-thioureas or squaramides with good to high stereocontrol (up to 89/11 dr and 98% ee).File in questo prodotto:
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