Five new cyclic peptoids containing (2S,4R)-4-hydroxyproline (Hyp) residues have been designed and synthesized using a mixed “submonomer/monomer” approach. Alkali metal cation affinities and ion transport activities were assessed by experimental (NMR and HPTS assay in liposomes) and computational methods. Easy functionalization of hydroxyproline residues afforded a bouquet of cyclic oligomers showing correlation between ion transport abilities and cytotoxic activities on selected human cancer cell lines.

Tuning the biomimetic performances of 4-hydroxyproline-containing cyclic peptoids

SCHETTINI, ROSARIA
Membro del Collaboration Group
;
COSTABILE, Chiara
Membro del Collaboration Group
;
G. Della Sala
Membro del Collaboration Group
;
I. Bruno
Membro del Collaboration Group
;
DE RICCARDIS, Francesco
Membro del Collaboration Group
;
I. Izzo
2018

Abstract

Five new cyclic peptoids containing (2S,4R)-4-hydroxyproline (Hyp) residues have been designed and synthesized using a mixed “submonomer/monomer” approach. Alkali metal cation affinities and ion transport activities were assessed by experimental (NMR and HPTS assay in liposomes) and computational methods. Easy functionalization of hydroxyproline residues afforded a bouquet of cyclic oligomers showing correlation between ion transport abilities and cytotoxic activities on selected human cancer cell lines.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11386/4716551
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