Inflammatory gene expression is modulated by posttranscriptional regulation via RNA-binding proteins (RBPs), which regulate mRNA turnover and translation by binding to conserved mRNA sequences. Their role in COPD is only partially defined. This study evaluated RBPs tristetraprolin (TTP), human antigen R (HuR), and AU-rich element-binding factor 1 (AUF-1) expression using lung tissue from COPD patients and control subjects and probed their function in epithelial responses in vitro.

Differential expression of RNA-binding proteins in bronchial epithelium of stable COPD patients

RICCIARDI, LUCA;DAL COL, JESSICA;MEMOLI, DOMENICO;Conti V;Vatrella A;PAPI, ANTONGIULIO;CARAMORI, GAETANO;Stellato C
2018-01-01

Abstract

Inflammatory gene expression is modulated by posttranscriptional regulation via RNA-binding proteins (RBPs), which regulate mRNA turnover and translation by binding to conserved mRNA sequences. Their role in COPD is only partially defined. This study evaluated RBPs tristetraprolin (TTP), human antigen R (HuR), and AU-rich element-binding factor 1 (AUF-1) expression using lung tissue from COPD patients and control subjects and probed their function in epithelial responses in vitro.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11386/4717454
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