H2S and its conjugate base HS- have recently gained increasing attention for their reactivity with bioinorganic targets. However, so far, stable adducts of bioinorganic compounds with H2S/HS- are still scarce due to the propensity of sulfide to form insoluble metal sulfides. In this work, we studied the reactivity of HS- with a family of fluorescent zinc complexes via a variety of spectroscopic techniques. The complexes selected for this study feature a pyridoxal moiety with different substituent groups on the ligand framework. Interaction of the complexes under investigation with HS- results in the displacement of the coordinated ligand from the Zn center with the concomitant precipitation of ZnS in the case of complexes 1 and 3, whereas for complex 2 our data points to the coordination of HS- to the metal center likely assisted by hydrogen bonding with the OH of the pyridoxal moiety. In the presence of HS-, the fluorescence emission of complex 2 is enhanced, whereas the fluorescence emission of complexes 1 and 3 is quenched. The results highlight the potential of complex 2 to be implemented as a HS- fluorescent sensor via a coordinative-based approach.

Interaction of monohydrogensulfide with a family of fluorescent pyridoxal-based Zn(ii) receptors

STRIANESE, Maria;Lamberti, Marina;Pellecchia, Claudio
2018-01-01

Abstract

H2S and its conjugate base HS- have recently gained increasing attention for their reactivity with bioinorganic targets. However, so far, stable adducts of bioinorganic compounds with H2S/HS- are still scarce due to the propensity of sulfide to form insoluble metal sulfides. In this work, we studied the reactivity of HS- with a family of fluorescent zinc complexes via a variety of spectroscopic techniques. The complexes selected for this study feature a pyridoxal moiety with different substituent groups on the ligand framework. Interaction of the complexes under investigation with HS- results in the displacement of the coordinated ligand from the Zn center with the concomitant precipitation of ZnS in the case of complexes 1 and 3, whereas for complex 2 our data points to the coordination of HS- to the metal center likely assisted by hydrogen bonding with the OH of the pyridoxal moiety. In the presence of HS-, the fluorescence emission of complex 2 is enhanced, whereas the fluorescence emission of complexes 1 and 3 is quenched. The results highlight the potential of complex 2 to be implemented as a HS- fluorescent sensor via a coordinative-based approach.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11386/4719230
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