The prevalence of chronic heart failure has increased progressively in recent years, becoming a common clinical and economic healthcare problem, mainly related to better survival from myocardial infarction, effective pharmacological and interventional treatments and aging of the population.Heart failure is a progressive disease that is characterized by left ventricular (LV) dilatation and loss of contractile function– a condition referred to as cardiac remodeling.The concept of LV reverse remodeling (LVRR) has been introduced to define a process characterized by a reduction in LV volumes with improvement in systolic and diastolic function at follow-up in patients with heart failure and reduced ejection fraction (HFrEF). Despite the proven association between LVRR and favorable prognosis, far less is known about its pathophysiology, predictive factors in clinical practice and its long-term consequences. Furthermore, very little evidence reports on LVRR not induced by cardiac resynchronization therapy (CRT) in patients with chronic HFrEF. Moreover, its definition is not straightforward; some echocardiographic studies used different aspects of LV systolic function but LV ejection fraction (LVEF) was considered the easiest marker to assess the improvement in cardiac pump. The aim of our study was to define LVRR predictors among demographic, clinical, electrocardiographic and echocardiographic data and evaluate the impact of LVRR on prognosis in a cohort of patients with chronic HFrEF after only optimal medical therapy (OMT)

Predictors of left ventricular reverse remodeling in patients with chronic heart failure

D'AURIA, FEDERICA
Writing – Original Draft Preparation
;
Polito, Maria V.
Data Curation
;
VITULANO, GENNARO
Methodology
;
Ciccarelli, Michele
Data Curation
;
Piscione, Federico
Supervision
;
Galasso, Gennaro
Writing – Review & Editing
2018

Abstract

The prevalence of chronic heart failure has increased progressively in recent years, becoming a common clinical and economic healthcare problem, mainly related to better survival from myocardial infarction, effective pharmacological and interventional treatments and aging of the population.Heart failure is a progressive disease that is characterized by left ventricular (LV) dilatation and loss of contractile function– a condition referred to as cardiac remodeling.The concept of LV reverse remodeling (LVRR) has been introduced to define a process characterized by a reduction in LV volumes with improvement in systolic and diastolic function at follow-up in patients with heart failure and reduced ejection fraction (HFrEF). Despite the proven association between LVRR and favorable prognosis, far less is known about its pathophysiology, predictive factors in clinical practice and its long-term consequences. Furthermore, very little evidence reports on LVRR not induced by cardiac resynchronization therapy (CRT) in patients with chronic HFrEF. Moreover, its definition is not straightforward; some echocardiographic studies used different aspects of LV systolic function but LV ejection fraction (LVEF) was considered the easiest marker to assess the improvement in cardiac pump. The aim of our study was to define LVRR predictors among demographic, clinical, electrocardiographic and echocardiographic data and evaluate the impact of LVRR on prognosis in a cohort of patients with chronic HFrEF after only optimal medical therapy (OMT)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11386/4720830
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