Over the last decade, more diverse populations have been included in genome-wide association studies (GWAS). If a genetic variant has a varying effect on a phenotype in different populations, GWAS applied to a dataset as a whole may not pinpoint such differences. It is especially important to be able to identify population-specific effects of genetic variants in studies that would eventually lead to development of diagnostic tests or drug discovery.
PopCluster: an algorithm to identify genetic variants with ethnicity-dependent effects
Puca, Annibale;
2019
Abstract
Over the last decade, more diverse populations have been included in genome-wide association studies (GWAS). If a genetic variant has a varying effect on a phenotype in different populations, GWAS applied to a dataset as a whole may not pinpoint such differences. It is especially important to be able to identify population-specific effects of genetic variants in studies that would eventually lead to development of diagnostic tests or drug discovery.File in questo prodotto:
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