A practical and mild approach to prepare tetrahydropyrazolo[1,2-a]-pyrazole-1,7-diones, bearing up to three stereocentres, by reacting ready available N,N′-cyclic azomethine imines and pyrazoleamides under catalytic loading of commercial 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD), has been developed. The products are obtained in good yields and high diastereoselectivity, working at room temperature. Preliminary bioassay showed the products to inhibit growth of Gram-positive bacteria. (Figure presented.).
1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD) Triggered Diastereoselective [3+2] Cycloaddition of Azomethine Imines and Pyrazoleamides
VOLPE, CHIARAInvestigation
;Meninno, SaraData Curation
;Capobianco, AmedeoSoftware
;Vigliotta, GiovanniInvestigation
;Lattanzi, Alessandra
Supervision
2019
Abstract
A practical and mild approach to prepare tetrahydropyrazolo[1,2-a]-pyrazole-1,7-diones, bearing up to three stereocentres, by reacting ready available N,N′-cyclic azomethine imines and pyrazoleamides under catalytic loading of commercial 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD), has been developed. The products are obtained in good yields and high diastereoselectivity, working at room temperature. Preliminary bioassay showed the products to inhibit growth of Gram-positive bacteria. (Figure presented.).File in questo prodotto:
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