Mitochondria are the heart unit of the cardiac cell because they are involved in the ATP production and in the transfer to the contractile apparatus. Furthermore, mitochondria modulate Ca2+ homeostasis, manage redox status and regulate response to cellular and environmental stresses. Abnormalities in mitochondrial organelle structure and function have been observed in many cardiovascular diseases, such as ischemic cardiomyopathy, heart failure and stroke but also in drug-induced cardiomyopathies. This review summarizes the recent literature in this field.

MITOCHONDRIA AND CARDIOVASCULAR DISEASE: A BRIEF ACCOUNT

Pecoraro, Michela
Writing – Original Draft Preparation
;
Pinto, Aldo
Supervision
;
Popolo, Ada
Conceptualization
2019-01-01

Abstract

Mitochondria are the heart unit of the cardiac cell because they are involved in the ATP production and in the transfer to the contractile apparatus. Furthermore, mitochondria modulate Ca2+ homeostasis, manage redox status and regulate response to cellular and environmental stresses. Abnormalities in mitochondrial organelle structure and function have been observed in many cardiovascular diseases, such as ischemic cardiomyopathy, heart failure and stroke but also in drug-induced cardiomyopathies. This review summarizes the recent literature in this field.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11386/4724152
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