Ultrasound-promoted N-aminomethylation of indoles can be achieved in basic medium using sodium hydride and dichloromethane (DCM) as C1 donor source. This innovative amino methylation protocol results in good to excellent yields of multifunctional indole derivatives. The procedure is also applicable to other aza-heterocyclic compounds and, interestingly, affords direct access to aminomethyl-substituted aryl alcohols.

An Efficient Approach to Aromatic Aminomethylation Using Dichloromethane as Methylene Source

Di Sarno Veronica;Musella Simona;Ciaglia Tania;Vestuto Vincenzo;Pepe Giacomo;MERCIAI, FABRIZIO;Campiglia Pietro;Bertamino Alessia
2019

Abstract

Ultrasound-promoted N-aminomethylation of indoles can be achieved in basic medium using sodium hydride and dichloromethane (DCM) as C1 donor source. This innovative amino methylation protocol results in good to excellent yields of multifunctional indole derivatives. The procedure is also applicable to other aza-heterocyclic compounds and, interestingly, affords direct access to aminomethyl-substituted aryl alcohols.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11386/4727815
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