OBJECTIVE To evaluate the current evidence and to identify associated risk factors that increase the incidence of this complication. Fluoroquinolone (FQ) has been considered the first-line therapy for uncomplicated urinary infections. FQ has been associated with Achilles tendon disorders, especially during the first month of treatment.METHODS Data sources searched included PubMed, MEDLINE, and Scopus from January 1988 to June 2017.RESULTS A total of 79 articles were used, with ciprofloxacin representing the most common drug.CONCLUSION We found that male gender, advanced age, normal body mass index, chronic renal failure, and concurrent use of corticosteroids increase the risk of Achilles tendon disorders. (C) 2017 Elsevier Inc.
Fluoroquinolones and the Risk of Achilles Tendon Disorders: Update on a Neglected Complication
Maffulli N.
2018-01-01
Abstract
OBJECTIVE To evaluate the current evidence and to identify associated risk factors that increase the incidence of this complication. Fluoroquinolone (FQ) has been considered the first-line therapy for uncomplicated urinary infections. FQ has been associated with Achilles tendon disorders, especially during the first month of treatment.METHODS Data sources searched included PubMed, MEDLINE, and Scopus from January 1988 to June 2017.RESULTS A total of 79 articles were used, with ciprofloxacin representing the most common drug.CONCLUSION We found that male gender, advanced age, normal body mass index, chronic renal failure, and concurrent use of corticosteroids increase the risk of Achilles tendon disorders. (C) 2017 Elsevier Inc.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
