Mesoglycan (MSG) was impregnated onto calcium alginate aerogel (CAA) to produce an innovative topical device to be applied on wounds. The main purpose of the composite material is to favor the re‐epithelialization through a direct and immediate action, also offering a protective barrier to ensure a favorable and sterilized environment for the wound healing process. Impregnation kinetics and isotherms were determined at 18 MPa and 40 and 60 °C. Composite systems were analyzed using Field Emission Scanning Electron Microscopy (FESEM), Differential Scanning Calorimetry (DSC), X-ray Diffraction (XRD), Fourier Transform Infrared (FT-IR) and UV–vis spectroscopies. A functional assay of in vitro wound healing confirmed the pro-migratory role of the composite system MSG/CAA, since an increase of the migration rate on fibroblast (BJ) cells and of the covered distance for keratinocytes (HaCaT) was observed with MSG impregnated on CAA compared to non-treated cells, CAA and pure MSG.
Supercritical impregnation of mesoglycan into calcium alginate aerogel for wound healing
Franco, PaolaInvestigation
;Pessolano, EmanuelaInvestigation
;Belvedere, RaffaellaInvestigation
;Petrella, AntonelloWriting – Original Draft Preparation
;De Marco, IolandaWriting – Original Draft Preparation
2020
Abstract
Mesoglycan (MSG) was impregnated onto calcium alginate aerogel (CAA) to produce an innovative topical device to be applied on wounds. The main purpose of the composite material is to favor the re‐epithelialization through a direct and immediate action, also offering a protective barrier to ensure a favorable and sterilized environment for the wound healing process. Impregnation kinetics and isotherms were determined at 18 MPa and 40 and 60 °C. Composite systems were analyzed using Field Emission Scanning Electron Microscopy (FESEM), Differential Scanning Calorimetry (DSC), X-ray Diffraction (XRD), Fourier Transform Infrared (FT-IR) and UV–vis spectroscopies. A functional assay of in vitro wound healing confirmed the pro-migratory role of the composite system MSG/CAA, since an increase of the migration rate on fibroblast (BJ) cells and of the covered distance for keratinocytes (HaCaT) was observed with MSG impregnated on CAA compared to non-treated cells, CAA and pure MSG.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
