In recent years, the endocannabinoid system has received great interest as a potential therapeutic target in numerous pathological conditions. Cannabinoids have shown an anticancer potential by modulating several pathways involved in cell growth, differentiation, migration, and angiogenesis. However, the therapeutic efficacy of cannabinoids is limited to the treatment of chemotherapy-induced symptoms or cancer pain, but their use as anticancer drugs in chemotherapeutic protocols requires further investigation. In this paper, we reviewed the role of cannabinoids in the modulation of signaling mechanisms implicated in tumor progression.

The Endocannabinoid System: A Target for Cancer Treatment

Laezza, Chiara
Supervision
;
Proto, Maria Chiara
Writing – Review & Editing
;
Fiore, Donatella
Writing – Review & Editing
;
Piscopo, Chiara
Writing – Review & Editing
;
Gazzerro, Patrizia
Supervision
;
Bifulco, Maurizio
Funding Acquisition
2020-01-01

Abstract

In recent years, the endocannabinoid system has received great interest as a potential therapeutic target in numerous pathological conditions. Cannabinoids have shown an anticancer potential by modulating several pathways involved in cell growth, differentiation, migration, and angiogenesis. However, the therapeutic efficacy of cannabinoids is limited to the treatment of chemotherapy-induced symptoms or cancer pain, but their use as anticancer drugs in chemotherapeutic protocols requires further investigation. In this paper, we reviewed the role of cannabinoids in the modulation of signaling mechanisms implicated in tumor progression.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11386/4734110
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