The first enantioselective method for the installation of the SCF3 group at the C-4 position of azlactones is described in the present communication under quinidinium phase transfer catalysis. The higher performance of substrates containing electron-rich 2-aryl groups at the azlactone was rationalized using DFT calculations.
Asymmetric trifluoromethylthiolation of azlactones under chiral phase transfer catalysis
Sicignano M.Investigation
;Capaccio V.Investigation
;Borello F.Investigation
;De Riccardis F.Investigation
;Della Sala G.
Conceptualization
;
2020
Abstract
The first enantioselective method for the installation of the SCF3 group at the C-4 position of azlactones is described in the present communication under quinidinium phase transfer catalysis. The higher performance of substrates containing electron-rich 2-aryl groups at the azlactone was rationalized using DFT calculations.File in questo prodotto:
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