The first enantioselective method for the installation of the SCF3 group at the C-4 position of azlactones is described in the present communication under quinidinium phase transfer catalysis. The higher performance of substrates containing electron-rich 2-aryl groups at the azlactone was rationalized using DFT calculations.

Asymmetric trifluoromethylthiolation of azlactones under chiral phase transfer catalysis

Sicignano M.
Investigation
;
Capaccio V.
Investigation
;
Borello F.
Investigation
;
De Riccardis F.
Investigation
;
Della Sala G.
Conceptualization
;
2020

Abstract

The first enantioselective method for the installation of the SCF3 group at the C-4 position of azlactones is described in the present communication under quinidinium phase transfer catalysis. The higher performance of substrates containing electron-rich 2-aryl groups at the azlactone was rationalized using DFT calculations.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11386/4740268
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