Background: The association between bariatric surgery (BS) and the prevention of type 2 diabetes (T2D) and its complications in patients with obesity has been rarely addressed in large nationwide database studies. Objective: To estimate the preventive effect of BS against T2D and its vascular complications in patients with obesity without comorbidity at baseline. Setting: All French public and private hospitals Methods: Data were extracted from the French National Health Service database between 2008 and 2016. All patients with obesity aged 18 to 60 years old, free of T2D and major comorbidities, and with at least one year of follow-up were analyzed. Patients who had undergone gastric bypass (GB), sleeve gastrectomy (SG), or adjustable gastric banding (AGB) were included in the BS group and patients with obesity with no history of BS were considered as controls. Results: Of the 328,509 patients with obesity included, 102,627 had BS. Between 2009 and 2016, 9.7% (31,946 of 328,509) of patients had a diagnosis of T2D associated with morbid obesity, 13.2% of the control group versus 2.0% of the BS group (p<0.001). BS was associated with favorable 8-year T2D event-free survival estimates of 92.3% in the BS group against 58.2% in the control group. The hazard ratio for the diagnosis of T2D was 0.18 (95% CI, 0.17 to 0.19) for the BS group versus controls, after adjustment on age, gender, BMI, and baseline differences. A significant difference was found between the type of bariatric procedure (p<0.001) with more T2D after AGB (4.5%) than after GB (1.2%) or SG (0.9%). T2D complications were more common in controls (p<0.001) with multiple T2D complications occurring in 1% of patients in the control group and 0.1% in the BS group (p<0.001). GB and SG were more effective than AGB. Conclusions: This nationwide study shows that BS reduces the new onset of T2D in patients with obesity by 82%. SG and GB give comparable results and both are more effective than AGB.
Preventive effect of bariatric surgery on type 2 diabetes onset in morbidly obese inpatients: a national French survey between 2008 and 2016 on 328509 morbidly obese
Schiavo L;
2019-01-01
Abstract
Background: The association between bariatric surgery (BS) and the prevention of type 2 diabetes (T2D) and its complications in patients with obesity has been rarely addressed in large nationwide database studies. Objective: To estimate the preventive effect of BS against T2D and its vascular complications in patients with obesity without comorbidity at baseline. Setting: All French public and private hospitals Methods: Data were extracted from the French National Health Service database between 2008 and 2016. All patients with obesity aged 18 to 60 years old, free of T2D and major comorbidities, and with at least one year of follow-up were analyzed. Patients who had undergone gastric bypass (GB), sleeve gastrectomy (SG), or adjustable gastric banding (AGB) were included in the BS group and patients with obesity with no history of BS were considered as controls. Results: Of the 328,509 patients with obesity included, 102,627 had BS. Between 2009 and 2016, 9.7% (31,946 of 328,509) of patients had a diagnosis of T2D associated with morbid obesity, 13.2% of the control group versus 2.0% of the BS group (p<0.001). BS was associated with favorable 8-year T2D event-free survival estimates of 92.3% in the BS group against 58.2% in the control group. The hazard ratio for the diagnosis of T2D was 0.18 (95% CI, 0.17 to 0.19) for the BS group versus controls, after adjustment on age, gender, BMI, and baseline differences. A significant difference was found between the type of bariatric procedure (p<0.001) with more T2D after AGB (4.5%) than after GB (1.2%) or SG (0.9%). T2D complications were more common in controls (p<0.001) with multiple T2D complications occurring in 1% of patients in the control group and 0.1% in the BS group (p<0.001). GB and SG were more effective than AGB. Conclusions: This nationwide study shows that BS reduces the new onset of T2D in patients with obesity by 82%. SG and GB give comparable results and both are more effective than AGB.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
