The growing number of patients on waiting lists for liver transplantation and the shortage of organs have forced many centres to adopt extended criteria for graft selection, moving the limit of acceptance for marginal livers. Steatotic grafts that were, in the past, considered strictly unacceptable for transplantation because of the high risk of early non-function, are now considered as a potential resource for organ implementation. Several methods to diagnose, measure, classify and stage steatosis exist but none can be considered qualitatively and quantitatively “the ideal method” to date. Clinical, biology and imaging data can be very helpful to estimate graft steatosis but histology still remains the gold standard. There is an increasing need for rapid and reliable tools to assess graft steatosis. Herein we present a comprehensive review of the approaches that are currently used to quantify steatosis in liver grafts.

Assessment of liver graft steatosis: where do we stand?

Schiavo L;
2019-01-01

Abstract

The growing number of patients on waiting lists for liver transplantation and the shortage of organs have forced many centres to adopt extended criteria for graft selection, moving the limit of acceptance for marginal livers. Steatotic grafts that were, in the past, considered strictly unacceptable for transplantation because of the high risk of early non-function, are now considered as a potential resource for organ implementation. Several methods to diagnose, measure, classify and stage steatosis exist but none can be considered qualitatively and quantitatively “the ideal method” to date. Clinical, biology and imaging data can be very helpful to estimate graft steatosis but histology still remains the gold standard. There is an increasing need for rapid and reliable tools to assess graft steatosis. Herein we present a comprehensive review of the approaches that are currently used to quantify steatosis in liver grafts.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11386/4746827
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